Job Dimensions:
The KEMRI-Wellcome Trust Collaborative Research Programme (KWTRP) researches diseases with the highest burden in developing countries for which it is recognised internationally within the fields of international public health, clinical tropical medicine, epidemiology and immunology. The programme aims to maximise opportunities for learning and training in order to maintain a cadre of highly skilled and experienced staff from all disciplines.
The goal of this funded G2P – Global Knowledge Exchange to Enable In Country Risk Assessment of SARS CoV-2 Variants is to assess the potential for spill-overs into domesticated and wild animal species and subsequent reservoir seeding; undertake in-country virological assessments of future virus outbreaks, and associated virus variants. To do this, the project will perform genomic surveillance of the viruses, immunological profiling and monoclonal antibody discovery. This position will be based at the KEMRI-Wellcome Trust Research Programme but will work collaboratively with external partners. The candidate will be expected to perform flowcytometry, cell sorting, molecular biology techniques such as library preparation, sequencing and sequence analysis and a range of serological assays including ELISA, Luminex and Neutralization.
Reports To:
Project Principal Investigator
Financial Responsibility:
None
Key Responsibilities:
Research
To perform serological assays such as Luminex, ELISA and virus neutralization assays
To perform molecular biology assays such as cloning, protein expression and purification
To perform flowcytometry and cell sorting
To prepare libraries for sequencing and analyse NGS sequencing data
To manage and update sample shipments from other labs and usage at KWTRP.
To keep accurate laboratory records on the assay development and data generation
Prepare and collate results, update relevant databases and prepare reports as may be required.
To contribute to development of scientific manuscripts
Qualifications:
A MSc degree in Molecular Biology or Biochemistry or related biological science
At least 3 years of research experience in a Research Laboratory.
Practical working knowledge of NGS sequencing.
The candidate should be familiar with cell culture and serological assays such as ELISA
The candidate will be expected to organize their work to changing priorities and possess excellent communication and interpersonal skills.
Evidence of ability to work independently
Desirable:
Experience in performing virus neutralization assays
Experience in running sequence analysis pipelines
Physical Environment/Conditions:
Based at the KEMRI/Wellcome Trust Research Programme in Kilifi, Kenya but flexible to travel to other partner or collaborating institutions
Be available to work out of hours if necessary.
Exposure to materials considered infectious and/or biohazards.
Competencies:
Demonstrate high levels of integrity and confidentiality
Excellent interpersonal, written, presentation and communication skills
Good analytical, problem solving and critical thinking skills;
Teamwork and ability to work with diverse teams
Strong Flexibility, adaptability, multi-tasking and attention to detail
Strong team coordination and Supervisory skills.
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